Abstract: Objective To observe the clinical effects of early enteral nutrition and ecoimmunonutrition in patients with primary liver cancer after hepatectomy. Methods 120 patients with primary liver cancer after hepatectomy were randomly divided into observation group （n=60） and control group （n=60）. In the control group, the patients were treated with routine enteral nutrition,while in the observation group the intervention including L-glutamine,L-arginine and bifid triple viable were given at the base of routine enteral nutrition. The postoperative serum liver function index,immunoglobulin,endotoxin,tumor necrosis factor alpha （TNF-α）,interleukin 6（IL-6）,peripheral blood CD4⁺ and CD8⁺ lymphocytes,general condition and gastrointestinal function were compared between the two groups. Results The levels of serum albumin,prealbumin,IgA,IgG,IgM,blood CD4⁺ and CD8⁺ in the observation group on the 7th postoperative day were （41.65±4.58） g/L,（196.65±25.64） mg/L,（2.12±0.56） g/L,（9.65±0.86） g/L,（0.98±0.25） g/L,（0.42±0.14） and（0.32±0.05）,much higher than those in the control group [（35.52±5.38） g/L and （178.38±30.54） mg/L,（1.83±0.48） g/L,（8.22±0.68） g/L,（0.80±0.25） g/L,（0.32±0.06） and（0.24±0.08）,P<0.05],while the levels of international normalized ratio,total bilirubin,direct bilirubin,endotoxin, TNF-α and IL-6 in the observation group were（1.05±0.16）,20.34±8.65） μmol,（11.35±2.38） μmol/L,（1.82 ± 0.25） ng/L,（258.62±28.65） pg/mL and （156.24±9.38） pg/mL,much lower than those in the control group [（1.46 ± 0.18）,（38.65±9.46） μmol,（19.35 ±4.28） μmol/L,（2.14±0.15） ng/L,（314.65±41.28） pg/mL and （171.35±20.38） pg/mL,P<0.05];the time of postoperative exhaust,defecation,ambulation,semifluid diet and hospitalization in the observation group were [（44.52±8.36） h,（74.35 ±14.68） h,（30.17±9.65） h,（85.34±16.25） h,and （10.25±1.88） d,significantly shorter than those in the control group [（68.65±10.48） h,（112.58±14.95） h,（41.35±10.38） h,（115.36±25.68） h,（14.58±2.36） d,P<0.05]. Conclusion Early enteral nutrition and ecoimmunonutrition can improve the nutritional status,improve immune function,reduce inflammation and liver damage,and promote early rehabilitation of patients with primary liver cancer after hepatectomy.

Key words: Hepatoma, Hepatectomy, Enteral nutrition, Ecoimmunonutrition, Clinical effect