Abstract: Objective The study was conducted to assess the efficacy of early administration of enteral nutrition （EN） in patients with hepatocellular carcinoma （HCC） undergoing hepatectomy. Methods A retrospective study was conducted in 130 HCC patients who undergoing surgical resection of hepatic tumor in our hospital between January 2015 and December 2017，and the diagnosis of HCC was approved by post-operational pathological examination. After hepatectomy，65 patients in observation received parenteral nutrition（PN） and EN，and another 65 in control received PN. Results At the end of two weeks after operation，serum albumin level in the observation was （41.4±2.9） g/L，prealbumin level was （260.8±12.5） mg/L，and Child-Pugh score was （5.7±1.7），significantly different as compared to [（34.6±2.5） g/L，（233.3±2.4） mg/L and（6.6±1.5），P<0.05] in the control；there were no significant differences in the blood liver tests between the two groups（P>0.05）；after operation，the excrement was（3.3±1.5）d，much earlier than 【（4.3±1.2）d，P<0.05】，while the hospitalization fee was（53696.3±16754.4） yuan，significantly higher than （50780.6±13632.7）yuan （P<0.05） in the control；the biliary leakage，infection，and liver insufficiency in observation group was 26.2%，no significantly different as compared to 32.2% in the control（P>0.05）. Conclusion Early administration of EN and PN combination in patients with HCC undergoing hepatectomy might elevate blood albumin levels，reduce post-operational complications and improve rehabilitation.

Key words: Hepatocellular carcinoma, Enteral nutrition, Parenteral nutrition, Perioperative period