Abstract: Objective To analyze cancerous XPO5 gene level changes in patients with hepatocellular carcinoma （HCC） and its clinical significance based on internet data bank. Methods The XPO5 mRNA in cancerous tissues in patients with HCC was analyzed by using Oncomine database and verified in TCGA GEPIA database. The methylation level of XPO5 gene in HCC tissues was analyzed by using MethHC database. The impact of XPO5 gene on the survival of patients with HCC was analyzed by GEPIA. The STRING database was used to analyze certain proteins interacted with XPO5. Results XPO5 mRNA was upregulated in cancerous tissues in patients with HCC compared with in normal liver tissues （P<0.01）,and its level increased mostly in cancerous tissues with pathological grading Ⅲ;the survival in HCC patients with high cancerous XPO5 mRNA level were significantly shorter than in patients with low XPO5 mRNA level（P<0.01）;low methylation in XPO5 gene body was found in HCC tissues （P<0.005）;the analysis of protein interaction network showed that XPO5 interacting with DICER1 and RAN proteins participated in miRNA regulation. Conclusion XPO5 gene is up-regulated in cancerous tissues in patients with HCC, which might be associated with prognosis of patients with HCC. At present,we can fully use internet database online to review the documented literature and provide reference for the biological treatment of patients with HCC.

Key words: Hepatocellular carcinoma, XPO5, Pathology, Prognosis, Database