Abstract: Objective To investigate the effects of sevoflurane inhalation on hepatic ischemia-reperfusion injury （HIRI） in patients with primary liver cancer （PLC） undergoing partial hepatectomy. Methods 60 patients with PLC undergoing selective partial hepatectomy were recruited in this study between July 2013 and July 2017,and were randomly divided into pre-inhalation,post-inhalation and whole-course inhalation group,with 20 cases in each group according to the time of sevoflurane inhalation difference. All patients received partial hepatectomy. The indexes of liver function,serum superoxide dismutase （SOD）,malondialdehyde （MDA）,serum prealbumin （PA） and C reactive protein （CRP）,and interleukin 6 （IL-6）,IL-10 and tumor necrosis factor-α （TNF-α） were measured and compared in the three groups. The blockage times of porta hepatis and block periods,the times of operation,the amounts of blood loss and hospital stay after operation were also recorded and compared. Results At the end of seven days after operation,serum ALT levels in pre-inhalation,post-inhalation and whole-course inhalation groups were （56.7±6.2） U/L,（148.2±13.2） U/L and （95.2±15.2） U/L,respectively （P<0.05）,serum AST levels were（40.4±10.1） U/L,（184.5±12.5） U/L and （134.2±15.6） U/L,respectively （P<0.05）,serum bilirubin levels were（29.8±6.7） μmol/L,（46.7±6.8） μmol/L and （35.1±6.7） μmol/L,respectively （P<0.05）,INR were （1.1±0.7）,（1.4±1.2） and （1.2±1.1）,respectively （P<0.05）;serum MDA levels were （9.4±3.6） U/L,（19.7±6.5） U/L and （11.4±4.9） U/L,respectively （P<0.05）,SOD levels were （36.7±6.4） nmol/mL,（13.4±5.2） nmol/mL and （24.8±16.7） nmol/mL,respectively （P<0.05）,PA levels were （159.8±15.8） mg/L,（102.1±16.3） mg/L and （129.9±21.2） mg/L,respectively （P<0.05）,and CRP levels were （29.3±1.2） mg/L,（44.8±3.5） mg/L and （33.6±1.6） mg/L,respectively （P<0.05）;serum IL-6 levels were （16.3±2.3） pg/ml,（9.6±2.4） pg/ml and （4.2±1.6） pg/ml,respectively （P<0.05）,IL-10 levels were （9.1±1.3） pg/ml,（5.2±2.5） pg/ml and （7.4±1.4） pg/ml,respectively （P<0.05）,and serum TNF-α levels were （15.4±2.7） pg/ml,（42.3±3.5） pg/ml and（28.4±2.7） pg/ml,respectively（P<0.05）. Conclusion The applicaton of sevoflurane pre-inhalation has efficacious protective effect on HIRI in PLC patients undergoing partial hepatectomy,which warrants further investigation.

Key words: Hepatoma, Partial hepatectomy, Sevoflurane, Hepatic ischemia-reperfusion injury