Abstract: Objective This study was aimed to investigate the enhanced magnetic resonance imaging(MRI) by gadolinium disodium sebacate （Gd-EOB-DTPA） in diagnosis of patients with focal liver lesions （FLL）.Methods A prospective study was conducted on 68 patients with suspected FLL by ultrasound and/or CT scan,and all the patients accepted Gd-EOB-DTPA enhanced MRI scan. The diagnosis of MRI was reevaluated by post-operational histopathological examination.Results The liver histopathological examination showed that hepatocullular carcinoma（HCC） in 36,intrahepatic cholangiocarcinoma in 6,mixed liver carcinoma in 8,hepatic focal nodular hyperplasia in 12,hepatic vascular leiomyolipoma in 4 and non-FLL in 2,while the enhanced MRI demonstrated that HCC in 37,intrahepatic cholangiocarcinoma in 7,mixed liver carcinoma in 4,hepatic focal nodular hyperplasia in 14,hepatic vascular leiomyolipoma in 2 and non-FLL in 4;the Kappa was 0.7 when the FLLs were diagnosed by MRI,with the sensitivity of 97.1%,specificity of 100.0%,positive predicting value of 100.0% and negative predicting value of 50.0%. Conclusion The application of MRI intensified by Gd-EOB-DTPA enhancement might be helpful in diagnosis of patients with FLL,which needs further validation in clinical practice.

Key words: Focal liver lesions, Hepatoma, Magnetic resonance imaging, Gadolinium disodium sebacate, Diagnosis