Abstract: Objective The aim of this study was to compare the efficacies on laparoscopic fenestration and ultrasound-guided puncture intervention for the treatment of patients with simple hepatic cyst （SHC）.Methods 94 patients with SHC were recruited in our Department of Interventional Ultrasound and Department of General Surgery between June 2017 and March 2018,and were randomly divided into control group and observation group,with 47 patients in each group. The patients in the control group were treated with laparoscopic fenestration,and those in the observation group were treated with ultrasound-guided puncture intervention. The liver function tests,adverse reactions and total effective rates were observed and compared between the two groups.Results One month after surgery,the total effective rates in both control group and the observation group were 100%;one month after surgery,serum levels of alanine aminotransferase（ALT）,aspartate aminotransferase（AST） and total bilirubin （TBIL） in the observation were （28.4±4.3） U/L,（28.5±2.3） U/L and （18.5±2.4） mmol/L,not significantly different as compared to （31.7±4.7） U/L,（31.3±2.4） U/L and （19.9±3.5） mmol/L in the control （P<0.05）;after surgery,the incidences of fever,abdominal distension and pain and vomiting in the observation were 14.9%,19.2% and 25.5%,significantly lower than 29.8%,42.6% and 48.9% （P<0.05） in the control. Conclusion The application of ultrasound-guided puncture intervention for the treatment of patients with SHC has the same total effective rate as with laparoscopic fenestration,which might reduce the incidence of adverse reactions,and is worthy for further investigations.

Key words: Simple hepatic cyst, Ultrasound-guided puncture intervention, Laparoscopic fenestration, Adverse reactions