Abstract: Objective To evaluate the value of serum angiopoietin-like protein 2（ANGPTL2） and Golgi protein 73 （GP73） levels in the diagnosis of liver fibrosis in patients with chronic hepatitis B（CHB）.Methods 117 patients with CHB were recruited in our hospital between March 2015 and October 2017,and serum ANGPTL2 and GP73 levels were detected by enzyme-linked immunosorbent assay. The efficacy of serum ANGPTL2 and GP73 levels in the diagnosis of significant hepatic fibrosis and cirrhosis were evaluated by the area under receiver operating characteristic curve （ROC）.Results Serum levels of ANGPTL 2 and GP73 in 15 CHB patients with S3-S4 were （9.1±2.4） ng/ml and （84.9±15.2） ng/ml,significantly higher than （6.7±2.3） ng/ml and （65.1±14.8） ng/ml （P<0.05） in 78 patients with S1-S2 or （4.4±1.4） ng/ml and （53.7±14.3） ng/ml in 24 patients with S0 （P<0.05）;based on serum ANGPTL2 levels equal to 8.6 ng/mL and equal to 9.6 ng/mL or serum GP73 level equal to 75.6 ng/ml and equal to 103.5 ng/mL as the cut-off-value for the diagnosis of significant hepatic fibrosis （equal to or greater than S3） and liver cirrhosis, the diagnostic efficacy of serum ANGPTL2 levels was not superior to serum GP73（Z=1.872,P=0.061;Z=0.328,P=0.743）;the diagnostic value of combination serum ANGPTL2 and GP73 levels for significant hepatic fibrosis was superior to either serum ANGPTL2 level or serum GP73 level alone,e.g. AUCcombination>AUCANGPTL2（Z=3.310,P=0.001） or AUCcombination>AUCGP73（Z=2.004,P=0.045）,while the diagnostic efficacy of combination serum ANGPTL2 and GP73 levels for liver cirrhosis was not superior to either serum ANGPTL2 or GP73 alone（Z=1.471,P=0.141;Z=1.575,P=0.115）;the efficacy of combination of serum ANGPTL2 and GP73 levels in diagnosis of liver fibrosis was not superior to FIB-4 or APRI（Z=0.869,P=0.386;Z=0.492,P=0.623） and it also not better than FIB-4 or APRI in diagnosis of liver cirrhosis（Z=1.834,P=0.067;Z=0.610,P=0.512）. Conclusion Serum levels of ANGPTL2 and GP73 change obviously in patients with CHB,which might hint hepatic fibrosis and be applied to evaluate the liver fibrosis staging.

Key words: Hepatitis B, Angiopoietin-like protein 2, Golgi protein 73, Liver fibrosis, Diagnosis