Abstract: Objective The purpose of this study was to explore the clinical value of dual-energy CT iodine quantification combined with dynamic contrast-enhanced MRI in evaluating liver hemodynamics and liver functions in patients with hepatitis B-induced liver cirrhosis （LC）. Methods 130 patients with hepatitis B cirrhosis and 30 individuals with normal liver function tests were recruited in our hospital between June 2016 and June 2018. The dynamic contrast-enhanced MRI scan and dual-energy CT enhanced scan were performed and the blood flow parameter peak （PV）,maximum rise slope（MSI）,maximum drop slope （MSD）,positive enhancement integral （PEI） and signal enhancement rate （SER） in the liver parenchyma were measured. The liver iodine concentration （Ia）,portal iodine concentration （Ip）,hepatic artery iodine fraction（AIF）,and portal iodine concentration （PVIC） were also calculated. Results The PV value of liver parenchyma in patients with LC was（522.1±96.7）,significantly lower than [（609.2±108.8）,P<0.05] in the control,and the liver parenchymal PEI value was （200.2±53.3）,significantly lower than [（241.3±61.5）,P<0.05] in the control;the PV value in 15 patients with CTP class C was（443.4±57.3）,significantly lower than [（587.4±94.5）,P<0.05] in 89 patients with CTP class A,the MSI value was（170.1±54.6）,significantly lower than [（310.6±69.5）,P<0.05] in patients with CTP class A,the MSD value was（31.9±22.5）,significantly lower than [（67.8±19.6）,P<0.05] in patients with CTP class A, the PEI value was （155.6±29.7）,significantly lower than [（236.7±53.4）,P<0.05] in patients with CTP class A,and the SER value was （109.3±7.5）,significantly lower than[（125.6±13.5）,P<0.05] in patients with CTP class A;the Ia value in 26 patients with CTP class B was （0.7±0.2） mgI/ml,in class C was （0.8±0.2） mgI/ml,both significantly higher than 【（0.5±0.1） mgI/ml,P<0.05】 in the control,and the Ip value in patients with CTP A was （2.2±0.5） mgI/ml,in patients with class B was （2.0±0.5） mgI/ml,in patients with class C was（1.8±0.3） mgI/ml,all significantly lower than 【（2.6±0.6） mgI/ml,P<0.05】 in the control,and AIF in patients with CTP class B was（31.7±5.0） %,and in those with class C was（47.8±8.9）%,both significantly higher than 【（21.1±4.3） %,P<0.05】 in the control. Conclusion Dual-energy CT iodine quantification combined with dynamic contrast-enhanced MRI is useful in clinical practice,which might help evaluate hepatic hemodynamics in patients with liver cirrhosis.

Key words: Liver cirrhosis, Hemodynamics, Dual energy CT, Magnetic resonance imaging, Perfusion parameters