Abstract: Objection The purpose of this study was to investigate the efficacy of early administration of enteral nutrition and microecological agents in patients with hepatic encephalopathy（HE）. Methods 64 patients with HE were randomly divided into observation and control group,with 32 cases in each group. The patients in control group were treated with routine therapy combined with early administration of enteral nutrition as patients awoke,while those in the observation group were treated with live bifidobacterium lactobacillus triple tablet at the base of the treatment in control group. All patients were followed-up for two weeks. Results At the end of the two-week observation,three and four patients in the control and in the observation died,respectively;the yeast-like fungi in the observation group was （3.2±0.4） CFU/g,significantly lower than （3.9±0.5） CFU/g in the control group （P<0.05）,while the aerobic enterococcus and lactobacillus anaerobicus in the observation group were （12.3±1.2） CFU/g and（9.7±0.7） CFU/g,significantly higher than （9.3±1.2） CFU/g and （8.2±0.8） CFU/g in the control group （P<0.05）;serum levels of endothelin,blood ammonia,interleukin-18 and tumor necrosis factor-α in the observation were （9.4±1.8） EU/mL,（75.4±10.2） μmol/L,（365.3±102.5） pg/mL and （26.3±10.7） ng/mL,significantly lower than （14.5±2.2） EU/mL,（109.3±15.5） μmol/L,（597.5±155.8） pg/mL and（42.8±11.2） ng/mL,respectively,in the control （P<0.05）;serum levels of albumin,plasma proalbumin,transferrin and retinol-binding protein in the observation group were （35.3±3.5） g/L,（341.1±35.2） mg/L,（2.5±0.4） g/L and （41.3±5.6） μg/L,significantly higher than （31.7±2.9） g/L,（310.1±33.4） mg/L,（2.2±0.4） g/L and（36.8±5.2） μg/L in the control（P<0.05）. Conclusion Early administration of enteral nutrition combined with microecological preparation might effectively improve intestinal flora disorders,inhibit inflammatory stress reaction,facilitate nutrient absorption,and improve liver function in patients with HE.

Key words: Hepatic encephalopathy, Enteral nutrition, Microecological agents, Intestinal flora, Therapy