Abstract: Objective To evaluate the clinical effects of combination of peginterferon and ribavirin in the treatment of patients with chronic hepatitis C. Method 58 patients with chronic hepatitis C received a combination of Pagasys（180μg/week）and ribavirin（800~1200mg/d）for 48 weeks. Liver function and level of HCV RNA were determined at the 12th,24th and 48th week during the treatment. Result The early virological response （EVR）rates and sustained virological response（SVR）rates in patients with genotype 1 were 57.1% and 53.6%,but in genotype non-1 patients those were 76.7% and 80%,respectively（P<0.05）;the early virological responserate in patients with high serum HCV RNA level was 56.3%,much lower than 80.8%（P<0.05）in patients with low serum HCV RNA level. Conclusion The response to the combination treatment in patients with chronic hepatitis C is influenced by genotype and the serum level of HCV RNA.

Key words: Hepatitis C, Peginterferon（α-2a）, Ribavirin, Therapy