Abstract: Objective To investigate the relationship of HBV genotype to liver biopsy and the antiviral therapy of nucleoside analogs. Methods We collected 541 patients with chronic hepatitis B virus infection. The patients were divided into 4 groups at random,e.g. lamivudine（n=136）,telbivudine（n=135）,entecavir（n=135）and adefovir（n=135cases）. The treatment lasted for 48 weeks. The genotype of HBV were determined by PCR before therapy. We also checked the liver function, HBV DNA and HBV M. Moreover,we performed the liver biopsies in 109 cases. Results The genotype B of HBV was 94 cases（17.38%）,type C was 410 cases（75.79%）,the type B/C was 37 cases（6.84%）,and no other types of genotype had been detected;in HBV genotype B,G3 in liver tissues accounted for 37.3% and S3 for 13.0%,while in HBV genotype C,G3 accounted for 8.7% and S3 for 22.7%（P<0.05）;in patients treated with lamivudine,telbivudine or entecavir,the efficacy in genotype B was better than patients with genotype C and B/C infection （P<0.05）. when we used adefovir therapy,there was no statistical significance（P>0.05）between genotype B and genotype C or B/C infection. Conclusion HBV genotype has close relationship with liver lesions and the antiviral therapy of nucleosides.

Key words: Hepatitis B, HBV genotypes, Liver biopsy, Nucleosides