Abstract: Objective To investigate the factors influencing postoperative recurrence in patients with primary liver cancer （PLC） after hepatectomy.Methods 163 patients with PLC were recruited in our hospital between June 2012 and June 2014， and they had hepatectomy and followed-up for two years. The clinical materials were retrospectively analyzed and the factors related to the recurrence of cancer after operation were evaluated by using multivariate Logistic regression analysis.Results Out of 163 patients with PLC，51 had，and 112 had not recurrence of tumor in two year follow-up period；the recurrent patients had higher percentage of underlying liver cirrhosis（80.39%），incomplete envelope of tumor （96.08%）， differentiated grade III and IV tumor cells （15.69%），multiple foci tumors（49.02%） and multiple-node fusion tumors （64.71%） than in non-recurrent patients （P<0.01）；multivariate Logistic regression analysis showed that liver cirrhosis，incomplete envelope，degree of differentiation，multiple foci and huge mass were independent risk factors for tumor recurrence after hepatectomy（P<0.05）.Conclusion HCC recurrence after resection is caused by many factors，including tumor size，liver cirrhosis，capsule integrity，differentiation degree of hepatocellular carcinoma，and multiple tumors，which might hint the risk of recurrence in patients with PLC after hepatectomy.

Key words: Primary liver cancer, Hepatectomy, Recurrence