Abstract: Objectiv The aim of this study was to evaluate the clinical efficacy of gastroscopic lauromacrogol injection in treatment of patients with liver cirrhosis and esophageal varices. Methods A retrospective analysis was performed in 80 patients with liver cirrhosis and esophageal varices who underwent endoscopic injection sclerotherapy （EIS） in our hospital between January 2016 and December 2017. Among them,38 patients underwent endoscopic injection with lauromacrogol and 42 cases underwent endoscopic injection of sodium morrhuate. All patients were followed-up for 12 months. The statistical analysis was performed on the disappearance of varices,hemostasis,postoperative complications and recurrence of varices during the followed-up periods. Results In lauromacrogol-injected group,the disappearance of varices and narrowed varices were 65.8% and 26.3%,not significantly different as compared to 69.0% and 26.2%,respectively,in sodium morrhuate-injected group（P>0.05）;the successful rate of emergent hemostasis and incidence of rebleeding in lauromacrogol-injected group were 92.1% and 34.2%, respectively,not significantly different as compared to 95.2% and 31.0%,respectively,in sodium morrhuate-injected group（P>0.05）;the incidence rates of postoperative complications such as fever,chest pain,ulcer and esophageal stricture in the lauromacrogol-injected group were 13.2%,13.2%,10.5% and 2.6%,respectively,which were significantly lower than 33.3%,38.1%,42.9% and 19.1% in sodium morrhuate-injected group（P<0.05）;at 3 months,6 months and 12 months of followed-up,the recurrence rates of varices in lauromacrogol-injected group were 10.53%,18.42% and 28.95%,respectively,not significantly different as compared to 9.52%,14.29% and 30.95%,respectively,in sodium morrhuate-injected group （P>0.05）. Conclusion The successful rate of hemostasis is as high as with morrhuate injection in patients with liver cirrhosis and esophageal varices undergoing gastroscopic injection of lauromacrogol, which might improve clinical efficacy with less postoperative complications. It is a safe and effective treatment regimen.

Key words: Liver cirrhosis, Esophageal varices, Sclerotherapy, Lauromacrogol, Endoscopy, Hemostasis, Recurrence