Abstract: Objective To compare the clinical effects of two different microwave antennas in the treatment of patients with hepatocellular carcinomas（HCCs）. Methods Under the guidance of ultrasonography,forty-three patients with HCC were ablated using the internally-cooled microwave antenna,and 17 patients with HCC were ablated using the non-internally cooded antenna. The therapeutic effects of the two antennas were compared. Results During therapeutic period,the complications（including local pain,the difficulty of drawing out the antenna,bleeding and skin burning） in the internally cooled antenna were fewer than those in the non-internally cooled antenna（P<0.05）;The coagulation necrosis by the internally-cooled antenna took a more round shape（P<0.01）,and the rate of carcinoma-remained in the ablation sites and 12-month recurrence in ablation by internally cooled antenna were obviously lower than in the non-internally cooled antenna（P<0.05）,while the rate of 12-month recurrence in liver in the two groups had no significant difference（P>0.05）. Conclusions Compared with the non-internally cooled microwave antenna,the internally cooled antenna boasts less complications and lower local recurrence for microwave ablation of HCCs.

Key words: Hepatocellular carcinoma, Microwave ablation, Microwave antenna, Therapy