原发性肝癌患者血清HBV标志物和HBV DNA测定的临床意义

doi:10.3969/j.issn.1672-5069.2012.05.0014

Abstract

Abstract: Objective To investigate the implication of serum hepatitis B viral HBV DNA in patients with primary liver cancer. Methods 151 patients with primary liverc cancer,132 patients with chronic hepatitis B,and 140 patients with liver cirrhosis were enrolled and serum markers of hepatitis B virus and HBV DNA were detected by using chemiluminescence and fluorescenct quantitative polymerase chain reaction. Results The serum markers of hepatitis B virus in 147 patients（97.35%） with primary liver cancer were positive,and serum HBV DNA positive rate was 74.8%（113/151） with an average load of 5.6±1.1 lgcopies/ml;in 90 patients（59.60%）with serum HBsAg,anti-HBe and anti-HBc positive,the serum HBV DNA positive rate was 76.7% with the average load of 5.1±0.9 lgcopies/ml,while in 38 patients（25.2%） with HBsAg,HBeAg and anti-HBc positive,the serum HBV DNA positive rate was 100.0% with the average HBV DNA load of 6.4±0.9 lgcopies/ml. Conclusion Hepatitis B virus infection rate was high in liver cancer patients,and it might play an important role in the hepatocarcinogenesis.

Key words: Hepatoma, Hepatitis B virus, HBV DNA load

Deng Qingmei, Gao Yong, He Wanwei, et al.. Implications of serum hepatitis B viral DNA in patients with primary liver cancer[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2012, 15(5): 414-416.

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Implications of serum hepatitis B viral DNA in patients with primary liver cancer

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