Abstract: Objective To investigate the clinical efficacy of autologous peripheral blood stem cell （PBSC） transplantation in patients with hepatitis B cirrhosis. Methods 95 patients with hepatitis B liver cirrhosis were recruited in our Department of Infectious Diseases between April 2014 and April 2017,and all the patients were randomly divided into transplantation （n=48） and control group （n=47）. The patients in the control group received entecavir and conventional supporting treatment,and the patients in the observation group were treated with intrahepatic transplantation of autologous PBSCs via hepatic artery at the base of supporting treatment. Peripheral blood T lymphocyte subgroups,liver stiffness,and serum tumor necrosis factor-α（TNF-α）,interleukin-6 （IL-6） and hypersensitive C reactive protein（hs-CRP） levels were assayed. Results At the end of 6 month treatment,total serum bilirubin level in patients receiving PBSCs transplantation was（16.4±1.2） μmol/L,significantly lower than （22.5±2.6） μmol/L （P<0.05） in the control,while serum albumin level was （35.2±4.0） g/L,much higher than （31.6±3.7） g/L（P<0.05） in the control;the percentage of peripheral blood CD3⁺ cells was （67.9±6.5）%,significantly higher than 【（60.3±5.5）%,P<0.05】,CD4⁺ cells was （42.7±3.8）%,significantly higher than 【（38.2±3.5）%,P<0.05】,and ratio of CD4⁺/ CD8⁺ cells was （1.5±0.2）,significantly higher than 【（1.4±0.1）,P<0.05】 in the control;the liver stiffness measurement was （7.1±0.1） kPa,much lower than [（7.9±0.1）kPa,P<0.05],and Child-Pugh score was （5.5±1.5）,much lower than [（7.4±2.3）,P<0.05] in the control;serum hs-CRP level was （18.9±5.6） pg/mL,much lower than [（25.2±7.9） pg/mL,P<0.05] in the control. Conclusion Autologous stem cell transplantation is short-term efficient in patients with hepatitis B liver cirrhosis,which might effectively improve the patient's immune functions,and decrease the blood cytokine levels.

Key words: Liver cirrhosis, Autologous peripheral blood stem cell transplantation, Lymphocyte subsets, Cytokines, Efficacy