Abstract: Objective To evaluate the efficacy of entecavir and peg-IFNα-2a or thymosin α1 combination in the treatment of patient with compensated hepatitis B liver cirrhosis. Methods In this study,88 patients with compensated hepatitis B cirrhosis were selected,and 38 received entecavir, 17 received entecavir combined with PEG-IFNα-2a and 33 received entecavir and thymosin α1 combination for 104 weeks. Results Serum HBV DNA levels in the entecavir monotherapy group before treatment and at the end of 104 week were （5.6±1.7） IU/ml and （1.0±0.7） IU/ml,respectively （P<0.05）,in PEG-IFNα-2a combination group were （5.8±1.3） IU/ml and （1.0±0.7） IU/ml,respectively（P<0.05） and in combined with thymosin group were （6.1±2.0） IU/ml and（1.0±0.9） IU/ml, respectively（P<0.05）;serum albumin levels in the entecavir group before treatment and at the end of 104 week were （43.1±5.4） g/L and （46.9±4.9） g/L,respectively （P<0.05）,and in combined thymosin group were （43.0±4.0） g/L and（46.8±5.4）g/L,respectively（P<0.05）;there were no significant differences as respect to liver stiffness measures and INRs among the three groups （P>0.05）. Conclusion Entecavir monotherapy could effectively inhibit the replication of HBV DNA, and improve liver function tests and we don’t find any advantages of combination with PEG-IFNα-2a or thymosin-α1 from the results of this study.

Key words: Liver cirrhosis, Hepatitis B, Entecavir, Peg-IFNα-2a, Thymosin-α1, Therapy