Abstract: Objective The purpose of this study to investigate the efficacy of adenosine methionine and glycyrrhizin combination in the treatment of patients with alcoholic cirrhosis and its effect on serum osteocalcin （BGP） levels. Methods A total of 276 patients with alcoholic cirrhosis were recruited in our hospital between March 2016 and February 2018,and were randomly divided into observation group （n=138） and control group （n=138）. The patients in the control group were given adenosine methionine enteric-coated tablets,and the patients in the observation were given an intravenous infusion of compound glycyrrhizin at the base of adenosine methionine administration for three weeks. Serum BGP levels were assayed by radioimmunoassay and serum IGF-1 levels were detected by enzyme-linked immunosorbent assay. Serum f hyaluronic acid （HA）,laminin （LN）,type IV collagen（IV-C） and type III procollagen（PCIII） were detected by chemiluminescence immunoassay. Results Serum albumin level in the observation group was（36.8±10.3） g/L,significantly higher than[（29.4±9.2） g/L,P<0.05] in the control group,serum bilirumin level was（26.4±5.1） μmol/L,significantly lower than [（47.3±9.4） μmol/L,P<0.05] in the control group,and serum GGT level was （158.6±72.8） U/L,significantly lower than[（254.6±100.4） U/L,P<0.05] in the control group;serum HA level in the observation group was （72.6±18.4） μg/L, significantly lower than [（158.4±30.5） μg/L,P<0.05] in the control,serum LN level was（87.4±8.3） μg/L, significantly lower than [（165.3±19.8）μg/L,P<0.05] in the control,serum PCIII level was（94.5±31.3） μg/L,significantly lower than[（147.4±42.5） μg/L,P<0.05] in the control,and serum IV-C level was（64.3±9.5） μg/L,significantly lower than[（98.4±26.4） μg/L,P<0.05] in the control;serum IGF-1 level in the observation group was（198.2±34.6） ng/ml,significantly higher than [（162.5±30.5） ng/ml,P<0.05] in the control,and serum BGP level was （8.8±3.9） ng/ml,significantly higher than [（6.7±3.0） ng/ml,P<0.05] in the control group. Conclusion Application of adenosine methionine and glycyrrhizin is efficacious in the treatment of patients with alcoholic cirrhosis,which can effectively improve liver function tests,and significantly increase serum IGF-1 and BGP levels.

Key words: Alcoholic cirrhosis, Adenosine methionine, Glycyrrhizin, efficacy, Osteocalcin