Abstract: Objective To investigate the efficacy of transcatheter arterial chemoembolization（TACE） combined with radiofrequency ablation（RFA） and Addie injection in the treatment of patients with primary liver cancer（PLC）. Methods A total of 76 PLC patients were recruited in our hospital between January 2013 and January 2015,and they were divided into the observation group （n=36） and the control group （n=40）,receiving combination of TACE, RFA and Addie and TACE and RFA,respectively. Serum C-reactive protein （CRP）,tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6）,and peripheral blood lymphocyte subsets were assayed. The quality of life was evaluated by Karnofsky’s score. Results There were significant difference in the disease control rate between the observation and the control group（91.7% vs. 72.5%） at the end of 3 month after treatment （P<0.05）;serum CRP,TNF-α and IL-6 levels were （109.8±13.2） mg/L,（0.5±0.2） pg/mL and （13.4±2.2） pg/mL in the observation group,significantly lower than [（156.2±20.4） mg/L,（1.1±0.2） pg/mL and （24.1±4.4） pg/mL in the control,P<0.05];the percentages of peripheral blood CD3+ and CD4+ cells and ratio of CD4+/CD8+ cells were（60.1±9.7）%,（44.3±8.3）% and （1.9±0.5）,respectively,significantly higher than [（52.2±9.9）%,（36.30±8.6） % and （1.4±0.3） in the control,P<0.05];the improvement rate of quality of life was significantly higher than that in the control group （80.5% vs. 57.5%,P<0.05）;at the end of 24 month followed-up,28（77.8%） survived in the observation group,while 29（72.5%） survived in the control（P>0.05）. Conclusions Addie injection,a herbal compound,might improve the quality of life in PLC patients receiving TACE and RFA therapy,which might be related to the reduction of inflammatory reaction,and enhance immune functions.

Key words: Hepatoma, Transcatheter arterial chemoembolization, Radiofrequency ablation, Addie injection, a hebal compound, Therapy