Abstract: Objective To evaluate the efficacy of cytokine-induced killer （CIK）,three-dimensional conformal radiotherapy（3D-CRT） and transcatheter arterial chemoembolization（TACE） in the treatment of patients with primary liver cancer （PLC）. Methods 51 patients with PLC were randomly divided into combination group （n=26）,receiving TACE/3D-CRT/CIK therapy,and control（n=25）,receiving TACE/3D-CRT therapy. Results At the end of one month therapy,the percentage of CD3+,CD4+,CD16+CD56+ and CD4+/CD8+ ratio in the combination group were （66.47±1.25） %,（56.98±2.65）%,（22.45±6.41） % and （1.52 ±2.10）,significantly higher than 【（53.17±0.98）%,（48.09±0.27）%,（19.74±1.88）% and（1.13±0.06）,P<0.05】,while that of CD8+ cells was（37.56±1.26）%,much lower than 【（42.67±4.35）%,P<0.05】 in the control;the improvement rate of life quality in combination group was 84.6%,significantly higher than that in the control group （52.0%,P<0.05）;the objective effective rate in the combination group was 92.3%,significantly higher than that in the control group（68.0%,P<0.05）;the 1-year survival rate in the combination group was 73.1%,significantly higher than that in the control group（52.1%,P<0.05）. Conclusion CIK cells combined radiotherapy and TACE for patients with PLC could improve the immune function,and patients' quality of life,which might lead to a good short-term efficacy and prolong the survival.

Key words: Hepatoma, Transcatheter arterial chemoembolization, Dimensional conformal radiotherapy, Cytokine-induced killer cells, Therapy