Abstract: Objective To explore the effect of tripterygium glycosides,azathioprine combined with diammonium glycyrrhizinate in the treatment of patients with autoimmune hepatitis（AIH）. Methods 68 patients with AIH were recruited in our hospital between January 2015 and January 2016,and the patients were randomly divided into control and observation group with 34 cases in each. The patients in the control group were treated with azathioprine and diammonium glycyrrhizinate,and the patients in the observation group were given tripterygium glycosides,azathioprine combined with diammonium glycyrrhizinate for 3 months. Before and after treatment,serum ALT,AST,ALP and TBIL,serum immunoglobulin and hepatic fibrosis index （HA,LN and PC III） levels were detected. Results At the end of 3 months treatment,serum ALT,AST,ALP and TBIL levels in the observation group were（51.7±7.2） U/L,（45.6±8.1） U/L,（67.4±3.2） U/L and（11.4±1.2） μmol/L,respectively, significantly lower than those in the control group [（79.7±11.9） U/L,（77.1±9.2） U/L,（87.1±4.0） U/L and （15.3±1.4） μmol/L,P<0.05];serum IgG,IgA and IgM levels in the observation group were （11.29±2.24） mg/ml,（2171.4±100.3） mg/L and（2218.8±98.2） mg/L,significantly lower than those in the control group[（14.80±2.75） mg/ml, （2839.9±107.0） mg/L and（2912.0±113.1） mg/L,P<0.05];and serum levels of HA,LN and PCⅢ were （112.4±6.8） μg/L,（61.3±4.6） μg/L and（52.4±3.3） μg/L,significantly lower than those in the control group [（164.2±7.3） μg/L,（82.6±5.7） μg/L and（79.2±4.4） μg/L,P<0.05];No serious adverse reaction was observed in the two groups. Conclusion Azathioprine,diammonium glycyrrhizinate,and tripterygium glycosides therapy have a better efficacy in patients with AIH in the short-term observation.

Key words: Autoimmune hepatitis, Tripterygium glycosides, Azathioprine, Diammonium glycyrrhizinate, Therapy