Abstract: Objective To explore the clinical efficacy of transcatheter arterial chemoembolization （TACE） combined with three-dimensional conformal radiation therapy（3D-CRT） in the treatment of patients with massive primary liver cancer（PLC）.Methods From January 2009 to January 2015，147 unresectable massive PLC（tumor size≥10 cm） patients in our hospital were divided into TACE plus 3D-CRT group （n=63） and TACE group（n=84） according to different treatment methods. Curative effects in the two groups were compared，and the adverse reaction during treatment period were recorded.Results The effective rate was 65.1% in the TACE plus 3D-CRT group，significantly higher than 40.5% in the TACE group （P＜0.05）；The 6-month，1-year and 2-year survival rates were 84.1%，55.6% and 27.0%，respectively，in the TACE plus 3D-CRT group，and 59.5% （P＜0.05），38.1% （P＜0.05） and 19.1% （P>0.05），respectively， in the TACE group；The adverse reactions in the two groups were not significantly different.Conclusion TACE combined with 3D-CRT therapy for unresectable massive PLC has good clinical efficacy.

Key words: Primary liver cancer, Transcatheter arterial chemoembolization, Three-dimensional conformal radiation, Therapy