Abstract: Objective To study the correlation between serum glycosylated hemoglobin（HbA1c） and non-alcoholic fatty liver diseases（NAFLD）. Methods A total of 12381 adult residents aged above 18 years in Kunming were enrolled in this study. The data including the waistline, body mass index（BMI）,blood pressure, fasting blood-glucose,blood lipids,glutamyltranspeptidase,HbA1c and the results of epigastrial B ultrasonography were recorded. According to the quartile of HbA1c levels,the participants were divided into four groups,e.g.,the HbA1c≤5.2% in Q1 group,5.2%<Q2 group≤5.4%,5.4%<Q3 group≤5.6%,and>5.6% in Q4 group. Logistic regression was conducted to predict independent risk factors for NAFLD. ResultsThe overall incidence of NAFLD in our series was 27.2% with 31.9% in male and 21.0% in female,which was significantly different （P<0.001）;The incidences of NAFLD in Q1,Q2,Q3 and Q4 group were 18.5% （534/2883）,22.8% （555/2436）,25.6%（840/3285） and 38.1%（1440/3777）,respectively,suggesting that the incidence of NAFLD increased with the rising HbA1c level;The systolic pressure,total cholesterol, low density lipoprotein cholesterol and fasting blood-glucose in 3369 NAFLD patients also elevated as blood HbA1c levels increased;Multiple Logistic regression analysis indicated that high HbA1c level was the risk factor for the incidence of NAFLD（OR=1.7,95%CI 1.2~2.4,P=0.007）. ConclusionBlood HbA1c levels is an independent risk factor for NAFLD and both of them are closely related to disorders of blood lipid metabolism.

Key words: Non-alcoholic fatty liver disease, Adult residents, Glycosylated hemoglobin, Risk factors