Abstract: Objectiv To investigate the clinical features and risk factors of liver injuries in patients with sepsis. Methods A retrospective analysis was performed in 117 patients with sepsis between 2013 and 2017. Out of them,58 were complicated by liver injury. The Logistic regression analysis was applied to explore the risk factors for sepsis-associated liver injury. Results In this series,the primary infection foci included abdomen （48.7%）,respiratory system（32.5%）,skin（7.7%）,urinary system（6.0%）,blood （1.7%）,cardiovascular system （0.9%）,gut（0.9%）,central nervous system（0.9%） and mediastina （0.9%）;the age of patients with liver injuries was （61.0±14.9） yr,significantly older than 【（52.6±18.0）yr,P<0.01】 in patients without,ICU stay was 【9（5,12）】 d, much longer than 【4（4,10）d,P<0.01】,SOFA score was（8.7±2.4）,significantly higher than 【（7.1±2.2）,P<0.01】,and APACHE II score was（21.9±6.4）,significantly higher than 【（18.4±6.0）,P<0.01】 in patients without;out of 58 patients with liver injuries,it presented as hyperbilirubinemia in 21,elevated serum ALT levels in 24 and mixed in 13,serum C-reaction protein levels in patients with different types of liver injuries were statistically different（P<0.05）,and the mortality in patients with mixed liver injuries was 53.8%,much higher than 9.6% in with hyperbilirubinemia or 33.3% in with elevated serum ALT levels（P<0.05）;multivariate analysis showed than the age and APACHE II score were the independent risk factors for liver injuries in patients with sepsis. Conclusion The older the patient with sepsis and the higher the APACHEII score are,the more chance the likelihood of liver damage occur in patients with sepsis,which might take into consideration in clinical practice and deal with properly in time.

Key words: Liver injury, Sepsis, Risk factors