Abstract: Objective The aim of this study was to investigate the pregnant outcomes in 112 patients with liver injuries during gestation periods. Methods A total of 112 patients with liver injuries during gestation periods and 50 healthy pregnant women with normal liver function tests were recruited in our hospital between April 2013 and April 2018,and the pregnant outcomes were recorded and compared between the two groups. Results Before delivery,serum alanine aminotransferase and aspartate aminotransferase peak levels in pregnant women with liver injuries were（146.0±46.4） U/L and （112.5±50.1） U/L,both returned back to normal after birth;the gestational duration,neonatal length and Apgar score at 60 s in pregnant women with liver injuries were not significantly different （P>0.05） as compared to those in control women,while postpartum blood loss was （206.9±80.1） ml,and neonatal body weight was （3086.3±252.4）g,much different as compared to those in the healthy women 【（189.8±72.2） ml and （3302.7±320.1） g,respectively,P<0.05】;the proportion of clean amniotic fluid in the women with liver injuries was 65.2%,much lower than 82.0% in the control,and the proportions of amniotic fluid contamination grade III,premature delivery,premature rupture of membranes and intrauterine neonatal respiratory distress in liver injury groups were 23.2%,17.0%,25.9% and 18.8%,significantly higher than 8.0%,2.0%,12.0% and 6.0% in the control group （P<0.05）. Conclusion Liver damage during gestation period might lead to untoward effects on maternal and fetal outcomes,which should taken into consideration and deal with carefully early.

Key words: Liver injury, Pregnancy, Pregnant outcome, Fetus, Premature delivery