Abstract: Objective To summarize the clinical features of herb-induced liver injury （HILI）. Methods Seventy-five patients with HILI were diagnosed by Uclaf causality assessment method（RUCAM） scores greater than 3 between January 2015 and December 2015. Results There were 59 patients with hepatocellular,11 with cholestatic and 5 with mixed injuries in this series;among the 75 cases,63 （84.0%） were acute HILI;in 39 patients with definite Chinese medicine ingredients,17 cases（43.6%） were caused by polygonum multiflorum;3 cases （60.0%） in mixed liver injuries had pruritus,significantly higher than 6 cases （10.2%） in patients with hepatocellular or 4 cases （36.4%） in cholestasitic liver injuries （P=0.00）;serum alanine aminotransferase level in patients with hepatocellular liver injury was （623.4±450.2） U/L,significantly higher than （84.4±57.4） U/L in patients with mixed or（179.5±75.5） U/L in those with cholestasis liver injury（P<0.05）;total serum bilirubin level in patients with hepatocellular,mixed and cholestasitic damages were（148.0±127.0） μmol/L,（150.8±102.6） μmol/L and（128.8±76.2） μmol/L,respectively（P>0.05）. Conclusion s Polygonum multiflorum is the most common cause of HILI,hepatocellular damage is more common in patients with HILI,and most cases presents as acute onset. The prognosis of patients with HILI is good.

Key words: Herb-induced liver injury, Traditional Chinese medicines, Clinical features