Abstract: Objective To analyze the changes in cirrhotic etiologies of inpatients from 2002 to 2011 in North China. Methods Cirrhotic etiologies and its changes were analyzed in 53092 patients with liver cirrhosis for the first time in our hospital from 2002 to 2011. Results Hepatitis B related cirrhosis（74.2%），hepatitis C related cirrhosis （10.8%），alcoholic cirrhosis （5.8%） and auto-immune liver diseases related cirrhosis （3.9%） were the top four etiologies；The percentage of hepatitis B related cirrhosis was decreased from 81.5% in 2002 to 66.8% in 2011，while the percentage of alcoholic cirrhosis was increased from 3.3% to 7.7%，a 2.3-time increase in 10 years；Patients with auto-immune liver diseases related cirrhosis were mainly female（84.3%） and patients with hepatitis B related cirrhosis and alcoholic cirrhosis were mainly male（80.0% and 98.0%，respectively，P<0.01）；The average age was less than 50 years in patients with alcoholic cirrhosis and hepatitis B related cirrhosis， while the average age was greater than 50 years old in patients with hepatitis C related cirrhosis and auto-immune liver diseases related cirrhosis （P<0.01）；For all patients，North China ranked first in patient’s family register，but for patients with alcoholic cirrhosis and auto-immune liver diseases related cirrhosis，Beijing and East China ranked the second and third place，respectively，in patient’s family register；The top three places accounted for 79.7% of patients with alcoholic cirrhosis；The improvement rate were greater than 70% in patients with the top four etiologies related cirrhosis，and the improvement rate were even higher （80%） in patients with alcoholic cirrhosis and auto-immune liver diseases related cirrhosis （P<0.01）. Conclusions Hepatitis B，hepatitis C，alcoho and auto-immune liver diseases are the top four etiologies of liver cirrhosis. The percentage of hepatitis B related cirrhosis is gradually decreasing，while the percentage of alcoholic cirrhosis is increasing from 2002 to 2011 in North China.

Key words: Liver cirrhosis, Etiology, Clinical features, Epidemic changes