Abstract: Objective To summarize the clinical characteristics of patients with human parvovirus B19 infection. Methods The clinical materials in 17 patients with human parvovirus （HPV） B19 infection was retrospectively summarized，and the clinical features，laboratory findings and radiologic imaging were analyzed. Results The predominant symptoms and signs of patients in this series were:fever（100.0%），general fatigue（82.4%）， arthralgia/myalgia （52.9%），pharyngalgia（17.4%），anorexia （64.7%），rash（17.3%），splenomegaly（70.6%），hepatomegaly （41.2%），lymphadenectasis（17.6%） and jaundice （17.3%）；The laboratory findings showed elevated serum alanine aminotransferase and aspartate transferase，lactate dehydrogenase，hydroxybutyrate dehydrogenase and adenosine deaminase levels，and higher lymphocyte counts; Hepatic injury caused by HPV B19 infection had features of acute onset and complicated clinical manifestations， but with a self-limited illness course. The recovery of liver function was rapid and the prognosis was relatively good. Conclusion The patients who have unexplained hepatic injury should have a prompt detection of serum anti-HPV B19 IgM，especially in those with negative serum hepatitis A，B，C and E virus markers.

Key words: Human parvovirus B19, Viral hepatitis, Clinical features