Abstract: Objective To investigate the change of liver function index and its correlation to blood lipids in patients with acute viral hepatitis （AVH）. Methods A total of 185 patients with AVH （47 cases of acute hepatitis A,63 cases of acute hepatitis B,4 cases of acute hepatitis C,39 cases of acute hepatitis E and 32 cases of acute undefined type of hepatitis） and 53 healthy people were recruited in this study. The serum levels of triglyceride（TG）,cholesterol（CHO）,high-density lipoprotein（HDL）,low density lipoprotein （LDL）,alanine aminotransferase （ALT）,aspartate aminotransferase（AST） and total bilirubin （TBIL） were measured. The SPSS 19.0 software was used and statistical analysis included parametric Methods （ANOVA,Pearson’s correlation coefficient） and nonparametric tests （Mann-Whitney U test,Spearman’s correlations coefficient）. Results The TBIL and TG in patients with acute hepatitis E [169.9（94.1~227.2） μmol/L and 2.44 （1.74~3.07） mmol/L] were higher than those in patients with acute hepatitis A [95.8（65.9~124.1） μmol/L and 1.9 （1.5~2.7） mmol/L],acute hepatitis B[65.2（38.9~126.3） μmol/L and 1.4（1.1~1.9） mmol/L],and acute undefined hepatitis [66.0（23.8~148.9） μmol/L and [2.2（0.8~1.3） mmol/L,P<0.01];serum CHO,HDL and LDL levels in patients with acute hepatitis E[（3.15±0.91） mmol/L,0.2（0.1~0.5） mmol/L and（1.6±0.7） mmol/L] were lower than those in patients with acute hepatitis A [（3.3±0.8） mmol/L,0.4（0.2~0.8） mmol/L and（1.8±0.7） mmol/L],acute hepatitis B[（3.5±0.8） mmol/L,0.6（0.3~0.9） mmol/L and （1.9±0.8） mmol/L], and acute undefined hepatitis [（3.9±1.0） mmol/L,0.7（0.4~1.0） mmol/L and [（2.2±0.8） mmol/L,P<0.05];there were significant negative correlation between ALT and CHO,HDL and LDL（r=0.478,r=0.524,r=0.416,P<0.01）,and between serum TBIL and CHO,HDL and LDL （r=-0.469,r=-0.713,r=-0.508,P<0.01）;there were significant positive correlation between serum TBIL and TG（r=0.629,P<0.01）. Conclusion The serum TG,CHO,HDL and LDL may be a sensitive indicator of liver function changes in patients with AVH.

Key words: Viral hepatitis, Liver function tests, Lipids