Abstract: Objective To observe the blood-lipid changes in patients with nonalcoholic fatty liver disease （NAFLD）. Methods This was a retrospective study of 638 patients in our hospital. We collected data including of liver function,blood-lipids,fasting blood-glucose（FBG）,HOMA-IR and hepatic CT scan. Results The blood-lipids in patients with NAFLD showed high level of TG. The degree of fatty liver was positively correlated with BMI and course of disease（P<0.05）. The levels of FBG,HOMA-IR,TC,APO-B,NON-HDL-C were increased gradually with the degree of fatty liver getting severe （P<0.05）. The levels of HDL-C,LDL,APO-A1 and TG had no obvious difference among the degree of fatty liver（P>0.05）. The level of ALT was positively correlated with degree of fatty liver,BMI and HOMA-IR,was negatively correlated with age（P<0.05）,but there was no difference in FBG and other blood-lipids. Conclusions Blood-lipids in patients with NAFLD showed high level of TG. The level of TC,APO-B and NON-HDL-C were increased gradually with the degree of fatty liver getting obvious,and there was no connection between ALT and blood-lipids.

Key words: Non-alcoholic fatty liver diseases, Blood-lipids, HOMA-IR