Abstract: Objective To investigate the changes of serum glycosylated hemoglobin（HbA1c） level and cardiac functions in patients with non-alcoholic fatty liver disease （NAFLD）. Methods A total of 118 patients with NAFLD and 60 healthy volunteers with matched age and gender were recruited in our hospital between May 2017 and May 2018,and the general data,including blood biochemistry,liver B-ultrasound and ultrasonic cardiogram parameters were collected in the two groups. The impacting factors of cardiac functions were evaluated by two-class Logistic regression analysis. Results The body mass index（BMI）,systolic blood pressure,diastolic blood pressure,fasting blood glucose,total cholesterol（TC）,triglyceride（TG）,low-density lipoprotein cholesterol （LDL-C）,uric acid,glutamyl transpeptidase （GGT） and HbA1c levels in patients with NAFLD were （26.8±5.6） kg/m²,（131.9±18.4） mmHg,（81.5±7.5） mmHg,（6.0±1.2） mmol/L,（5.4±0.7） mmol/L,（1.8±0.4） mmol/L,（3.2±0.6） mmol/L,（334.2±46.7） μmol/L,（39.4±9.0） U/L and （6.0±1.2）%,significantly higher than（23.4±5.0） kg/m²,（125.4±16.9） mmHg,（77.3±6.9） mmHg,（5.3±1.1） mmol/L,（4.9±0.6） mmol/L,（1.3±0.4） mmol/L,（2.9±0.6） mmol/L,（290.4±40.2） μmol/L,（22.2±5.7） U/L and（5.4±1.2）% （P<0.05） in healthy individuals,while serum high-density lipoprotein cholesterol （HDL-C） level was lower than that in the control group [（1.4±0.4） mmol/L vs. （1.6±0.4） mmol/L,P<0.05];the left ventricular end-diastolic volume（LVEDV） and incidence rate of diastolic cardiac dysfunction（DCD） in 43 patients with NAFLD and elevated blood HbA1c level were （48.3±5.3） mm and 27.91%,significantly higher than（45.2±4.7）mm and 9.33% （P<0.05） in 75 patients with normal HbA1c levels,and the left ventricular ejection fraction （LVEF） and E/A ratio were（53.0±11.3）% and （1.0±0.2）,significantly lower than （59.9±12.3）% and [（1.1±0.3）,P<0.05] in the latter;Logistic analysis showed that HbA1c,LVEDV and GGT were the independent risk factors for occurrence of DCD in patients with NAFLD,while the LVEF was a protective factor （P<0.05）. Conclusions Patients with NAFLD are often associated with elevated blood HbA1c levels,which might be the risk factor for DCD or coronary heart disease in patients with NAFLD.

Key words: Non-alcoholic fatty liver diseases, Glycosylated hemoglobin, Cardiac function