Abstract: Objective To investigate the implication of plasma thyroid stimulating hormone （TSH） levels in patients with nonalcoholic fatty liver disease（NAFLD） and type 2 diabetes mellitus （T2DM）. Methods 43 patients with NAFLD and T2DM and 40 with T2DM were admitted to our hospital,and the patient's age,gender,height,body mass,body mass index（BMI）,insulin resistance index（HOMA IR）,systolic blood pressure,diastolic blood pressure,blood biochemical parameters and free three iodine thyroid original glycine（FT3）,free thyroxine（FT4） and TSH were compared between the two groups. Results The BMI in patients with NAFLD and T2DM was （28.4±3.8） kg/m²,significantly higher than（23.8±3.1） kg/m² in patients with T2DM （P<0.05）;serum ALT,AST,gamma glutamyl transpeptidase,triglyceride,HOMA-IR and TSH levels in patients with NAFLD and T2DM were much higher than those in patients with T2DM（P<0.05）;serum TC,TG,LDL-C and FT3 levels in three groups of NAFLD patients with different serum TSH levels were significantly different （P<0.05） as the patients with NAFLD were divided into low（n=14）,middle（n=16） and high（n=13） serum TSH levels;the Logistic analysis showed that BMI（RR=1.720,95%CI:1.154-3.015）,HOMA-IR（RR=2.632,95%CI:1.010-3.654）,serum TSH（RR=2.577,95%CI:1.214-3.689） and TG levels（RR=1.538,95%CI:1.240-2.658） were the independent risk factors for the occurrence of T2DM in patients with NAFLD. Conclusion The clinicians should take the risk factors of T2DM occurrence in patients with NAFLD into consideration in clinical practice for early prevention and intervention,and the detection of serum TSH level might be helpful in dealing with patients in this settings.

Key words: Non-alcoholic fatty liver disease, Type 2 diabetes, Thyrotropin, Screening