Abstract: Objectiv The aim of this study was to explore the application of acoustic radiation force impulse （ARFI） quantification in the evaluation of liver injuries in patients with non-alcoholic fatty liver disease （NAFLD）. Methods Clinical data of 31 patients with nonalcoholic simple fatty liver（NAFL）,31 with obvious non-alcoholic steatohepatitis（NASH） and 31 with significant NASH,diagnosed by liver pathological examination, and 31 normal persons were retrospectively analyzed. The mean ARFI values at 4 cm,6 cm and 8 cm in left and right livers were detected by sonography. Results The mean ARFI values of 4 cm,6 cm and 8 cm sites in the left liver of patients with normal persons,NAFL,obvious NASH and significant NASH were（1.32±0.15） m/s,（1.25±0.12） m/s,（1.18±0.11） m/s and （1.05±0.10） m/s,in right liver of the three sites were（1.08±0.09） m/s,（0.94±0.08） m/s,（0.89±0.09） m/s and （0.84±0.07） m/s, and the whole liver ARFI of right and left were （1.19±0.10） m/s,（1.10±0.09） m/s,（1.02±0.08） m/s and（0.93±0.08）m/s,showing the significantly decreased ARFI value in patients with significant NASH （P<0.05）;the ARFI of the four groups at 8 cm in left liver were （1.18±0.14）m/s,（1.02±0.13）m/s,（0.87±0.15）m/s and（0.71±0.11） m/s,at 6 cm in right liver were （1.06±0.10） m/s,（0.95±0.09）m/s,（0.90±0.08）m/s and（0.85±0.07）m/s,and at 8 cm in right liver were （1.02±0.07）m/s,（0.91±0.06） m/s,（0.81±0.08）m/s and （0.72±0.05）m/s,all showing decreased ARFI value in patients with significant NASH （all P<0.05）. Conclusions ARFI quantification might be used to evaluate the liver injuries in patients with NAFLD,which needs further investigation.

Key words: Non-alcoholic fatty liver disease, Non-alcoholic steatohepatitis, Ultrasonography, Acoustic radiation force impulse technique, Diagnosis