Abstract: Objectives To investigate the implication of serum apolipoprotein B（ApoB） levels and its correlation with metabolic syndrome（MS） in checked-up individuals. Methods The physical examination was carried out in 1451 individuals between February 2015 and November 2017 in our hospital,and they were screened for nonalcoholic fatty liver disease （NAFLD） by ultrasonography and FibroTouch. Serum ApoB level was assayed routinely. The influencing factors of NAFLD occurrence was analyzed by Logistic regression analysis. Results Out of the 1451 individuals,the incidence of NAFLD was 24.8%;serum ApoB level in 360 patients with NAFLD was（1.07±0.24）g/L,significantly higher than【（0.88±0.27） g/L,P<0.01】 in 1091 individuals without NAFLD;serum ApoB levels were divided into Q1（<0.73 g/L） in 263,Q2（0.73~0.85 g/L） in 364,Q3（0.86~0.99 g/L） in 321,Q4（1.0~1.16 g/L） in 300 and Q5（≥1.17 g/L） in 203 persons,and their morbidity of NAFLD were 4.2%,9.9%,19.0%,25.0% and 34.5%,suggesting higher incidence rate of NAFLD in those with higher serum ApoB levels（P<0.05）;in the same way,the incidence rates of various clinical types of MS,such as visceral obesity,hypertension,hypertriglyceridemia and hyperglycemia,increased as serum ApoB levels increased;multivariate Logistic regression analysis showed that gender,diastolic blood pressure,body mass index,blood lipids,fasting blood glucose and serum ApoB levels were the independent risk factors for NAFLD occurrence. Conclusion Elevated serum ApoB level might hint the existence of NAFLD,which warrants further check-up in clinical practice.

Key words: Non-alcoholic fatty liver disease, Apolipoprotein B, Blood lipids, Metabolic syndrome