Abstract: Objective To investigate the implication of serum IL-10 and GP73 levels in patients with HBV-related acute-on-chronic liver failure（HBV-ACLF）. Methods Serum IL-10 and GP73 levels were measured by ELISA in fifty-six patients with HBV-ACLF,thirty-two patients with chronic hepatitis B （CHB）,and twenty healthy persons. All patients with HBV-ACLF were followed-up for 3 months. Results At presentation,serum IL-10 level in patients with HBV-ACLF were （32.4±14.8） pg/ml,significantly higher than （15.2±6.3） pg/ml in patients with CHB or（6.1±1.9） pg/ml in healthy control （P<0.05）,and serum GP73 level in patients with HBV-ACLF were （283.4±95.4） ng/ml,also significantly higher than （129.7±58.1） ng/ml in patients with CHB or （45.5±16.2） ng/ml in the control（P<0.05）;at baseline,serum IL-10 levels in 33 survivals with HBV-ACLF were （34.6±15.3） pg/ml,significantly higher than（30.1±14.3） pg/ml in 23 dead ones（P<0.05）,and there was no significant difference between the survival and the dead as respect to their serum GP73 levels [（279.7±94.5） ng/ml vs. （287.2±96.2） ng/ml,P=0.36];two weeks after treatment,serum IL-10 levels in survival group with HBV-ACLF were （30.1±14.0） pg/ml,still significantly higher than （24.9±11.2） pg/ml in dead group （P<0.05）,and there was a significant difference of serum GP73 levels in the survival and dead [（258.7±85.9） ng/ml vs.（331.2±107.5） ng/ml,P<0.05]. Conclusion The HBV-ACLF patients with high serum IL-10 level might have a relatively good prognosis,and the dynamic detection of serum GP73 level might be of certainly significance in assessing short-term prognosis of patients with HBV-ACLF.

Key words: Acute-on-chronic liver failure, IL-10, GP73