Abstract: Objective To explore the risk factors for occurrence of hyperbilirubinemia in neonates.Methods 86 neonates with hyperbilirubinemia and another 86 healthy neonates were recruited in the Department of Neonatology in our hospital between May 2015 and February 2018,and the Logistic analysis were applied for the analysis of risk factors.Results The proportion of caesarean delivery,short gestational age and decreased body mass at birth in neonates with hyperbilirubinemia were significantly higher than in healthy neonates（P<0.05）;serum level of myoglobin and prealbumin in neonates with hyperbilirubinemia were（37.5±13.6） U/L and（79.9±23.5） U/L,much lower than [（63.2±18.4） U/L and （108.6±27.3）U/L,P<0.05],serum GGT and AST levels were （141.7±45.9） U/L and （39.8±13.1）U/L,significantly higher than[113.6±39.3） U/L and（33.4±12.6） U/L,respectively,P<0.05] in the healthy neonates;multivariate Logistic regression analysis showed that body mass at birth（OR=6.2,P=0.003）,gestational age（OR=2.8,P=0.004）,myoglobin （OR=3.4,P<0.001）,prealbumin （OR=2.9,P=0.001）,GGT（OR=3.2,P=0.011）,AST（OR=3.7,P=0.024） and PT were the risk factors for the occurrence of hyperbilirubinemia in neonates. Conclusion The liver function index in neonates with hyperbilirubinemia are damaged,and monitoring the risk factors related to hyperbilirubinemia and taking timely measures to intervene are helpful to reduce the incidence of untoward outcomes.

Key words: Hyperbilirubinemia, Neonatal, Risk factors, Logistic regression analysis