Abstract: ObjectiveTo investigate the recurrence factors for esophageal varices after endoscopic eradication therapy of endoscopic sequential variceal ligation plus sclerotherapy（EVLS）. MethodsSixty-one patients with esophageal varices achieved eradication standards after EVLS therapy were followed up for 2 years. The patients were divided into high recurrence risk group （relapse within 24 months） and low recurrence risk group （without recurrence within 24 months） according to the recurrence time,and the biochemical and clinical data of the two groups were collected and analyzed statistically. Results There were 24（39.3%） cases of patients diagnosed with esophageal variceal recurrence within two years,and 37（60.7%）without recurrence. There were significant differences between the two groups as respect to bleeding history,spleen hyperthyroidism,diabetes,moderate/severe ascites, Child-Push scores,serum albumin,platelet counts,prothrombin time and portal vein diameters measured by ultrasound（P<0.05）;Furthermore,non-conditional logistic regression analysis showed that bleeding history,moderate/severe ascites and diabetes history were independent risk factors for esophageal varices recurrence（OR value 9.7,6.5 and 10.8,respectively）. Conclusions Bleeding history,moderate/severe ascites and diabetes history are independent risk factors for esophageal varices recurrence and these patients should be actively followed up and retreated in time.

Key words: Esophageal varices, Endoscopic eradication therapy, Relapse, Risk factors