Abstract: Objective The aim of this study was to investigate the anesthetic efficacy of target-controlled infusion of (TCI) in accordance with propofol in partial hepatectomy. Methods Eighty-six patients with primary liver cancer (PLC) undergoing partial hepatectomy in our hospital between April 2017 and January 2019 were randomly divided into study group and control group with 43 in each. The patients in the control group were given routine anesthesia and those in the study group were anesthetized with remifentanil combined with propofol at the manner of TCI. The extubation time, eye opening time, spontaneous respiratory recovery time, stress response index and standard for coming out of the awakening room (Aldrete) were compared between the two groups. Modified vigilance sedation scale (OAA/S) score was obtained and the complications between the two groups were compared. Results The extubation time, the eye opening time and spontaneous respiratory recovery time in patients in the study group were significantly shorter than those in the control group [(12.7±3.3) min, (10.1±3.2)min and (9.4±2.1)min, vs. (18.4±5.2)min, (17.6±3.4)min and (16.4±5.4)min, respectively, P<0.05】; there was no significant difference in stress response index between the two groups at T0 (P > 0.05), while the level of stress response index in the study group was better thanthat in the control group (P < 0.05) during the operation; immediately after extubation and 15 minutes after extubation, the Aldrete scores in the study group were (9.4±0.7) and (9.4±0.8), and the OAA/S scores were (4.3±0.4) and (4.7±0.4), significantly higher than [(8.3±0.4) and (8.9±0.5), and (3.4±0.4) and (4.2±0.5), respectively, P<0.05】 in the control; the incidence of adverse reactions in the study group was 11.6%, significantly lower than 27.9% in the control (P < 0.05). Conclusion The application of the compound propofol TCI anesthesia is appropriately applied to the partial hepatectomy, and the stress reaction during the operation could be effectively reduced, which might improve the recovery of patients with PLC after operation.

Key words: Hepatoma, Partial hepatectomy, Remifentanil, Propofol, Target-controlled infusion, Anesthesia