慢性肝病患者肝组织巨噬细胞功能变化研究新进展*

doi:10.3969/j.issn.1672-5069.2020.01.040

Abstract

Abstract: Objective Macrophages play a crucial role in maintaining homeostasis and repairing tissue damage. Macrophages in the liver can be further divided into Kupffer cells with self-renewal capacity, as well as monocyte-derived macrophages. On the one hand, macrophages can resist the damage of viruses, drugs and other unfavorable factors, and promote the recovery of liver tissue injuries; On the other hand, it also promote the recovery of hepatitis and cirrhosis. In this review, we focus on recent research advances in the classification and functions of liver macrophages and their roles in different liver diseases.

Key words: Viral hepatitis, Alcoholic liver disease, Non-alcoholic fatty liver disease, Hepatoma, Macrophage, Functions

Xu Ling, Ren Feng. Roles ofhepatic macrophages in several common liver diseases[J]. Journal of Practical Hepatology, 2020, 23(1): 145-148.

References

[1] Davies L C, Jenkins S J, Allen J E, et al. Tissue-resident macrophages.Nat Immunol,2013,14(10):986-995.
[2] Tacke F, Zimmermann H W. Macrophage heterogeneity in liver injury and fibrosis. J Hepatol,2014,60(5):1090-1096.
[3] Gammella E, Buratti P, Cairo G, et al. Macrophages: central regulators of iron balance. Metallomics,2014,6(8):1336-1345.
[4] Lavin Y, Winter D, Blecher-Gonen R, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell,2014,159(6):1312-1326.
[5] Gammella E, Buratti P, Cairo G, et al. Macrophages: central regulators of iron balance. Metallomics,2014,6(8):1336-1345.
[6] Auffray C, Fogg D K, Narni-Mancinelli E, et al. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med,2009,206(3):595-606.
[7] Hettinger J, Richards D M, Hansson J, et al. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol,2013,14(8):821-830.
[8] Varol C, Mildner A, Jung S. Macrophages: development and tissue specialization. Annu Rev Immunol,2015,33:643-675.
[9] Ingersoll M A, Spanbroek R, Lottaz C, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood,2010,115(3):e10-e19.
[10] Varol C, Mildner A, Jung S. Macrophages: development and tissue specialization. Annu Rev Immunol,2015,33:643-675.
[11] Heymann F, Tacke F. Immunology in the liver--from homeostasis to disease. Nat Rev Gastroenterol Hepatol,2016,13(2):88-110.
[12] Reid D T, Reyes J L, Mcdonald B A, et al. Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation. PLoS One,2016,11(7):e159524.
[13] Lavin Y, Winter D, Blecher-Gonen R, et al. Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell,2014,159(6):1312-1326.
[14] Tu Z, Bozorgzadeh A, Pierce R H, et al. TLR-dependent cross talk between human Kupffer cells and NK cells. J Exp Med,2008,205(1):233-244.
[15] You Q, Cheng L, Kedl R M, et al. Mechanism of T cell tolerance induction by murine hepatic Kupffer cells. Hepatology,2008,48(3):978-990.
[16] Okabe Y, Medzhitov R. Tissue biology perspective on macrophages. Nat Immunol,2016,17(1):9-17.
[17] Wree A, Marra F. The inflammasome in liver disease. J Hepatol,2016,65(5):1055-1056.
[18] Amaral S S, Oliveira A G, Marques P E, et al. Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun Signal,2013,11(1):10.
[19] Kim H Y, Kim S J, Lee S M. Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion. FEBS J,2015,282(2):259-270.
[20] Wree A, Eguchi A, Mcgeough M D, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology,2014,59(3):898-910.
[21] Noel G, Arshad M I, Filliol A, et al. Ablation of interaction between IL-33 and ST2+ regulatory T cells increases immune cell-mediated hepatitis and activated NK cell liver infiltration. Am J Physiol Gastrointest Liver Physiol,2016,311(2):G313-G323.
[22] Surewaard B G, Deniset J F, Zemp F J, et al. Identification and treatment of the staphylococcus aureus reservoir in vivo. J Exp Med,2016,213(7):1141-1151.
[23] Jalan R, Fernandez J, Wiest R, et al. Bacterial infections in cirrhosis: a position statement based on the EASL Special Conference 2013. J Hepatol,2014,60(6):1310-1324.
[24] Claria J, Stauber R E, Coenraad M J, et al. Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure. Hepatology,2016,64(4):1249-1264.
[25] Laursen T L, Rodgaard-Hansen S, Moller H J, et al. The soluble mannose receptor is released from the liver in cirrhotic patients, but is not associated with bacterial translocation. Liver Int,2017,37(4):569-575.
[26] Heymann F, Tacke F. Immunology in the liver-from homeostasis to disease. Nat Rev Gastroenterol Hepatol,2016,13(2):88-110.
[27] Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology,2014,147(3):577-594.
[28] You Q, Holt M, Yin H, et al. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol,2013,86(6):836-843.
[29] Mossanen J C, Krenkel O, Ergen C, et al. Chemokine (C-C motif) receptor 2-positive monocytes aggravate the early phase of acetaminophen-induced acute liver injury. Hepatology,2016,64(5):1667-1682.
[30] Bartneck M, Fech V, Ehling J, et al. Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease. Hepatology,2016,63(4):1310-1324.
[31] Wiktor S Z, Hutin Y J. The global burden of viral hepatitis: better estimates to guide hepatitis elimination efforts. Lancet,2016,388(10049):1030-1031.
[32] Boltjes A, Movita D, Boonstra A, et al. The role of Kupffer cells in hepatitis B and hepatitis C virus infections. J Hepatol,2014,61(3):660-671.
[33] Shrivastava S, Mukherjee A, Ray R, et al. Hepatitis C virus induces interleukin-1beta (IL-1beta)/IL-18 in circulatory and resident liver macrophages. J Virol,2013,87(22):12284-12290.
[34] Broering R, Wu J, Meng Z, et al. Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication. J Hepatol,2008,48(6):914-922.
[35] Angulo P, Kleiner D E, Dam-Larsen S, et al. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology,2015,149(2):389-397.
[36] Duffield J S, Forbes S J, Constandinou C M, et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest,2005,115(1):56-65.
[37] Mossanen J C, Tacke F. Role of lymphocytes in liver cancer. Oncoimmunology,2013,2(11):e26468.
[38] Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol,2016,13(3):316-327.
[39] Zhou S L, Zhou Z J, Hu Z Q, et al. Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib. Gastroenterology,2016,150(7):1646-1658.

Roles ofhepatic macrophages in several common liver diseases

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Liu Jian, Zhu Fengfa, Tang Juan. Ultrasonographic and biochemical features of patients with non-alcoholic heterogeneous fatty liver [J]. Journal of Practical Hepatology, 2020, 23(1): 42-45.
[2]	Wei Zhongcao, Liu Na, Xing Xin, et al. Efficacy and safety ofpolyene phosphatidylcholine combined with metformin in the treatment of patients with non-alcoholic fatty liver disease: a Meta-analysis [J]. Journal of Practical Hepatology, 2020, 23(1): 46-49.
[3]	Mao Chongshan, Yin Hui, Xiao Erhui, et al. Effects of fenofibrate on blood lipids, vascular endothelial functions and liver fibrosis in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus [J]. Journal of Practical Hepatology, 2020, 23(1): 50-53.
[4]	Sun Hongju, Wang Yanyan, Xu Congcong, et al. Efficacy of tiopronin and metoprolol combination in treatment of patients with alcoholic liver disease [J]. Journal of Practical Hepatology, 2020, 23(1): 54-57.
[5]	Zhou Xiaoxu, Zhang Huajie. Evaluation of fetal cardiac functions by velocity vector imaging in pregnant women with intrahepatic cholestasis of pregnancy [J]. Journal of Practical Hepatology, 2020, 23(1): 62-65.
[6]	Chen Liang, Duan Haifeng, Yu Hongxing. Detection of tumor foci blood supply by SMI, CDFI and enhanced CT in patients with primary liver cancer after TACE [J]. Journal of Practical Hepatology, 2020, 23(1): 90-93.
[7]	Ma Ning, Dai Xiaowen , Wu Jianjiang. Influence of different types of liquid infusion on clinical efficacy and safety of patients withhepatocellular carcinoma undergoing partial hepatectomy [J]. Journal of Practical Hepatology, 2020, 23(1): 102-105.
[8]	Guo Hualei, Bu Lilin, Pei Ying, et al. Effect of Chinese herbal medicine on serum TNF-α and leptin levels in rats with NAFLD [J]. Journal of Practical Hepatology, 2020, 23(1): 138-141.
[9]	Shi Xiaolong, Du Rui, Qin Geping, et al. Protective effect of sevoflurane on sepsis-induced liver injury in rats [J]. Journal of Practical Hepatology, 2019, 22(5): 640-643.
[10]	Zhang Xu Lei, Yang Qingyu, Han Qiuyu, et al. Short-term efficacy of herbal medicine in treatment of patients with nonalcoholic fatty liver disease [J]. Journal of Practical Hepatology, 2019, 22(5): 660-663.
[11]	Liu Xing, Zhao Shuli, Zhang Dianlong. Effect of sevoflurane inhalation on hepatic ischemia-reperfusion injury in patients with primary liver cancer undergoing partial hepatectomy [J]. Journal of Practical Hepatology, 2019, 22(5): 728-731.
[12]	Pei Ying, Huang Feng, Yin Hongzhen, et al. Preliminary study on intestinal microecology in mice with xenograft hepatoma intervened by sodiumnorcantharidate [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 486-489.
[13]	Yan Xisheng, Li Wei, Wang Jian, et al. Changes of serum cytokines and intestinal flora distribution in patients with alcoholic liver diseases [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 518-521.
[14]	Xie Xiao, Liu Ting, Dong Zhixia, et al. Value of controlled attenuation parameter in diagnosis of individuals with liver steatosis by using Fibrotouch [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 526-529.
[15]	Dai Qingyun, Wang Rundong, Jia Weidong. Prediction of early tumor recurrence by predictive nutritional index in patients with hepatocellular carcinoma undergoing hepatectomy [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 561-564.