非酒精性脂肪性肝病患者磁共振质子密度脂肪分数变化

doi:10.3969/j.issn.1672-5069.2021.03.014

Abstract

Abstract: Objective The paper aimed to analyze the clinical implication of magnetic resonance imaging-proton density fat fraction (MRI-PDFF) in patients with nonalcoholic fatty liver diseases (NAFLD).Methods 64 patients with NAFLD were enrolled in our hospital between January 2018 and September 2020, and all underwent sonography, liver biopsies and MRI scan. The MRI-PDFF was obtained.Results Out of the 64 patients with NAFLD, the sonography showed mild, moderate and severe fatty liver in 20 cases, 28 cases and 16 cases, and the body mass index, blood fats, fasting blood glucose levels and MRI-PDFF in patients with severe fatty liver were all significantly higher than those in patients with mild or moderate fatty liver (P<0.05); the liver histopathological examination demonstrated no liver tissue steatosis (S0) , S1, S2 and S3 in 8 cases, 22 cases, 25 cases and 9 cases, with the MRI-PDFF of (3.2±1.4)%, (8.7±6.3)%, (15.4±5.0)% and (22.8±7.4)%, respectively, significantly different among them (P<0.05), the liver active inflammation grading (G)1 , G2 and G3 were in 14 cases, 36 cases and 14 cases, with the MRI-PDFF of (8.6±7.5)%, (10.9±9.8)% and (14.6±11.3)%, significantly different among them (P<0.05), and the liver fibrosis (F)0 in 18 cases, F1 in 24 cases, F2 in 14 cases, F3 in 6 cases and F4 in 2 cases, with the MRI-PDFF of being (4.6±3.2)%, (9.4±8.1)%, (10.6±7.4)%, (11.3±10.6)% and (7.1±3.4)%, significantly different among them (P<0.05).Conclusion The MRI-PDFF changes and significantly different in patients with different degree of fatty liver, which might help the early diagnosis of patients with hepatic steatosis easily.

Key words: Nonalcoholic fatty liver disease, Magnetic resonance imaging-proton density fat fraction, Hepatic steatosis, Diagnosis

Jia Qunling, Xu Zhibin, Han Shu. Implication of magnetic resonanceimaging-proton density fat fraction in patients with nonalcoholic fatty liver diseases[J]. Journal of Practical Hepatology, 2021, 24(3): 359-362.

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Implication of magnetic resonanceimaging-proton density fat fraction in patients with nonalcoholic fatty liver diseases

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