颅内出血患者合并非酒精性脂肪性肝病情况分析

doi:10.3969/j.issn.1672-5069.2021.03.016

Abstract

Abstract: Objective The aim of this study was to investigate the prevalence of nonalcoholic fatty liver diseases (NAFLD) in patients with intracerebral hemorrhage (ICH).Methods A total of 146 patients with ICH were treated in our hospital between January 2010 and June 2020, and all underwent sonography for the diagnosis of NAFLD. The univariate and multivariate Logistic regression analysis was applied to confirm the factors for NAFLD coexistence.Results Out of our series, 52 patients (35.6%) were found with underlying NAFLD; the percentage of type two diabetes mellitus (T2DM) in patients with NAFLD was 32.7%, significantly higher than 12.8%(P<0.05) in patients without NAFLD, the body mass index in patients with NAFLD was (25.4±2.4)kg/m², significantly higher than [(23.1±2.7)kg/m², P<0.05] in patients without NAFLD, the blood high-density lipoprotein (HDL) level in patients with NAFLD was (1.4±0.5) mmol/L, significantly lower than (1.8±0.5) mmol/L in patients without NAFLD, the blood triglyceride level was (4.2±1.6)mmol/L, significantly higher than [(2.2±1.1)mmol/L, P<0.05] in patients without NAFLD, the percentage of large intracerebral bleeding volume in patients with NAFLD was 75.0%, significantly higher than 39.4%(P<0.05) in patients without NAFLD, and the percentage of lowGlasgow coma score (GCS) in patients with NAFLD was 67.3%, significantly higher than 37.2%(P<0.05) in patients without NAFLD, while there were not significant differences as respect to the percentages of high blood pressure, smoking, cardiovascular diseases, vascular malformation, increased fasting plasma glucose, serum alanine aminotransferase and aspartate aminotransferase, and infection between the two groups(P>0.05); multivariate Logistic analysis showed that coincidence of T2DM, large intracerebral bleeding and lower GCS were the independent risk factors for underlying NAFLD in this circumstance, and normal blood HDL level was the protective factor for patients without NAFLD(P<0.05). Conclusions The presence of T2DM, intracerebral hematoma volume greater than 30 ml and GCS score less than 10 in patients with ICH might hints the presence of NAFLD, which remind the clinicians dealing appropriately with them in clinical practice.

Key words: Nonalcoholic fatty liver diseases, Intracerebral hemorrhage, Glasgow coma score, Hyperlipoproteinemia

Jin Ying, Zhou Weizhen, Feng Shibing, et al. Prevalence of nonalcoholic fatty liver diseases in patients with intracerebral hemorrhage[J]. Journal of Practical Hepatology, 2021, 24(3): 367-370.

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Prevalence of nonalcoholic fatty liver diseases in patients with intracerebral hemorrhage

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