非酒精性脂肪性肝炎患者肝脏受控衰减参数的变化

doi:10.3969/j.issn.1672-5069.2021.02.016

Abstract

Abstract: Objective The purpose of this study was to investigate the early screening of nonalcoholic steatohepatitis (NASH) detected by FibroScan with liver controlled attenuation parameters (CAP) .Methods 142 patients with NASH and 130 healthy individuals were recruited in our hospital between January 2016 and January 2020,and underwent Fibroscan for CAP. All patients received liver biopsies and the nonalcoholic fatty liver disease activity score (NAS) was defined. The area under the receiver operating characteristic curve (AUROC)was obtained for evaluating the diagnostic efficacy of CAP in predicting NASH.Results The cap in patients with NASH was (291.1±94.5) dB / m, which was significantly higher than that in healthy persons [(216.2±43.1) dB/m, P<0.001]; the cap values in 60 patients with NAS of four, 39 patients with NAS of five, 27 patients with NAS of six and 16 patients with NAS of seven were (247.4±20.4)dB/m, (282.4±25.2)dB/m, (352.4±31.4)dB/m and (372.4±27.0)dB/m,P＜0.001】, significantly different among them; the ROC analysis showed that the AUC of CAP was 0.865(SE:0.025, 95%CI=0.815-0.915, P＜0.001), with optimal cut-off-value of 293.7 dB/m, and the sensitivity of 0.831 and specificity of 0.885.Conclusion The CAP might help quantitatively screening Nash in physical examination, and warrants further investigation.

Key words: Nonalcoholic steatohepatitis, Transient elastography, Controlled attenuation parameter, Diagnosis

Yang Zhenhui, Gu Baohuan, Dai Xiaoling. Early screening of nonalcoholic steatohepatitis by FibroScan with liver controlled attenuation parameters[J]. Journal of Practical Hepatology, 2021, 24(2): 212-215.

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Early screening of nonalcoholic steatohepatitis by FibroScan with liver controlled attenuation parameters

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