Abstract: Objective The aim of this study was to investigate serum reactive oxygen species (ROS) and adiponectin (ADPN) level changes in patients with chronic hepatitis B (CHB) and non-alcoholic fatty liver diseases (NAFLD).Methods 97 patients with CHB and NAFLD and 97 patients with CHB were recruited in our hospital between January 2018 and January 2020, and serum ROS, ADPN and tumor necrosis factor-α (TNF-α) were detected by ELISA. The liver fibrosis was assessed by NAFLD fibrosis scoring (NFS) system. The liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were detected by FibroScan.Results Serum GGT level in patients with CHB and NAFLD was (96.5±13.3)U/L, significantly higher than 【(67.3±12.5)U/L, P<0.05】 in patients with CHB; serum FPG, TC, TG and LDL-C levels in patients with CHB and NAFLD were (5.9±1.0)mmol/L, (5.2±1.1)mmol/L, (2.8±0.4)mmol/L and (2.8±0.4)mmol/L, all significantly higher than 【(4.9±1.0)mmol/L,(4.1±0.8)mmol/L,(1.7±0.3)mmol/L and (2.2±0.3)mmol/L, respectively, P<0.05】, while serum HDL-C was (0.9±0.2)mmol/L, much lower than 【(1.2±0.2)mmol/L, P<0.05】 in patients with CHB; serum ROS and TNF-α levels were (1.7±0.4)U/mL and (32.6±5.4)ng/L, both significantly higher than 【(0.9±0.2)U/mL and (21.5±4.8)ng/L,P＜0.05】, while serum ADPN level was (8.7±1.9)ng/mL, much lower than 【(10.2±2.3)ng/mL, P＜0.05】 in patients with CHB; the NFS score, LSM and CAP were (0.2±0.1), (10.2±1.3)kPa and (287.4±44.3)dB/m, all significantly higher than 【(-1.4±0.1), (9.1±1.2)kPa and (242.5±38.7)dB/m, respectively, P＜0.05】 in patients with CHB.Conclusion Serum ROS level significantly increases, while serum ADPN level greatly decreases in patients with CHB and NAFLD, and the mechanism by which they take part in the pathogenesis of the coexisted entity needs further investigation.

Key words: Non-alcoholic fatty liver disease, Hepatitis B, Reactive oxygen species, Adiponectin, Controlled attenuation parameter