空气污染物PM2.5与非酒精性脂肪性肝病发病研究进展

doi:10.3969/j.issn.1672-5069.2021.02.038

Abstract

Abstract: Objective The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is related to insulin resistance (IR) and lipid metabolism disorders. Currently, the widely accepted hypothesis of NAFLD is the "multiple hits theory". Studies have reported that inhalation of ambient particular matter (PM) 2.5 could induce oxidative stress and inflammation in liver tissues, impacting liver lipid metabolism and causing liver cell damage. In addition, PM2.5 is also closely related to IR, obesity and fat synthesis signaling pathways. This review will summarize the relationship between IR, obesity, lipid metabolism and PM2.5, and analyze the potential impact of PM2.5 on the pathogenesis of NAFLD, which might have implications for the prevention and treatment of the entity.

Key words: Non-alcoholic fatty liver disease, Insulin resistance, Obesity, Lipid metabolism, Ambient particular matter 2.5

Wu Weijie, Fan Jiangao. Is ambient particular matter 2.5 correlated to pathogenesis of nonalcoholic fatty liver disease?[J]. Journal of Practical Hepatology, 2021, 24(2): 297-300.

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Is ambient particular matter 2.5 correlated to pathogenesis of nonalcoholic fatty liver disease?

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