Abstract: Objective The aim of this study was to investigate whether laparoscopic sleeve gastrectomy (LSG) might improve liver enzyme and glycolipid metabolism disorders in obese persons with nonalcoholic fatty liver disease (NALFD). Methods 73 obese persons with NALFD were admitted to our Department of General Surgery, Second Affiliated Hospital, from May 2016 through August 2018, and all underwent LSG . The patients were followed-up for six months. Results Out of all the patients, 36 were male and 37 were female, with an average age of (31.7 ± 7.4) years; the body weight and body mass index (BMI) at the end of six months after operation were (89.0 ± 16.4) kg and (31.1 ± 4.4) kg/ m², significantly lower than (120.0±23.5) kg and (42.2±6.7) kg/m² before the surgery (P<0.01); serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and glutamyl aminotransferase levels were ( 28.6±11.3) U/L,(19.3±8.6) U/L, (67.2±15.8) U/L and (27.5±13.1) U/L, significantly lower than (61.4±23.2) U/L, (37.3±12.3) U/L,(83.2±21.3) U/L and (54.4±17.2) U/L, respectively, before surgery (P<0.01); serum fasting blood glucose, triglyceride and total cholesterol levels were (5.1±0.6) mmol/L ,(1.0±0.5) mmol/L and (4.3±1.0) mmol/L, significantly lower than (6.0±1.7)mmol/L,(1.7±0.9) mmol/L and (4.7±1.6) mmol/L, respectively, before surgery (P<0.05), while serum albumin and total bilirubin levels were (42.9±2.8) g/L and (10.9±4.9) μmol/L, not significantly different as compared to (42.8±4.2) g/L and (11.0±5.2)μmol/ L, respectively, before surgery (P>0.05). Conclusion LSG surgery could improve liver enzyme and glycolipid metabolism disorders in obese persons with NAFLD, which needs further and long-term investigation.

Key words: Nonalcoholic fatty liver disease, Obesity, Laparoscopic sleeve gastrectomy, Glycolipid metabolism