Abstract: Objective The aim of this study was to investigate the clinical implications of soluble cluster of differentiation 163 (sCD163) and interleukin (IL)1βmRNA in patients with nonalcoholic steatohepatitis (NASH). Methods 51 patients with NASH and 51 healthy persons were enrolled in the Department of Gastroenterology in our hospital between January 2016 and March 2018, and serum levels of sCD163, visfatin and adiponectin were detected by ELISA, and blood IL-1βmRNA was assayed by RT-PCR. Results Blood glucose, low density lipoprotein (LDL-C) , triglyceride (TG) and total cholesterol levels in patients with NASH were (6.1±1.4)mmol/L,(3.6±1.1)mmol/L,(2.9±0.4)mmol/L and (6.1±0.6)mmol/L, significantly higher than [(4.5±0.3)mmol/L,(2.5±0.9)mmol/L,(2.2±0.2)mmol/L and (4.5±0.3)mmol/L, respectively, P<0.05】 in the control; serum sCD163, IL-1βmRNA, visfatin and adiponectin levels in patients with NASH were (70.7±10.4) ng/ml, (0.5±0.1), (31.1±8.4)μg/ml and (6.8±1.3)μg/ml, significantly different compared to 【(30.8±5.9) ng/ml, (0.1±0.2), (15.9±2.6)μg/ml ad (15.2±2.2)μg/ml, respectively, P<0.05】 in healthy persons; serum alanine aminotransferase, aspartate aminotransferase and gamma glutamyltranspeptidase levels in patients with NASH were(73.5±3.9)U/L, (62.7±2.8)U/L and (108.0±4.1)U/L, significantly higher than 【(33.5±3.9)U/L, (32.7±2.8)U/L and (48.0±4.1)U/L, respectively, P<0.05】 in healthy persons. Conclusion The patients with NASH have abnormal liver function tests, blood glucose and lipid metabolism imbalance, besides, they have elevatedserum sCD163, IL-1βmRNA and visfatin levels, and decreased adiponectin levels, which might hint liver injuries and poor prognosis.

Key words: Non-alcoholic steatohepatitis, Soluble cluster of differentiation 163, Interleukin (IL) 1β mRNA, Visfatin, Adiponectin