Abstract: Objective Non-alcoholic fatty liver diseases (NAFLD) is the most common type of chronic liver disease all over the world, which is related to metabolic abnormalities and oxidative stress. The purpose of this study was to assess the effects of calorie restriction diet on insulin resistance, lipid profile and oxidative stress index in patients with NAFLD. Methods 124 patients with NAFLD were recruited in our hospital From January 2018 through January 2019, and were randomly divided into group A and group B, with 62 in each. The daily calorie intake in groupA was controlled at 1200～1500 kcal.d^-1 on the premise of ensuring protein, basic vitamin and trace element intake, the patients in group B designed their own diets forthemselves. The study lasted for 12 weeks. Results At presentation, there was no significant differences in fasting blood glucose (FPG), insulin, insulin resistance index (HOMA-IR), islet B cell function (HOMA-B) and insulin sensitivity detection index (QUICKI) between the two groups (P>0.05), while at the end of 12 weeks of observation, the HOMA-IR in group A was (3.5±2.0) , significantly lower than [(4.7±2.2), P < 0.05) in group B, and the QUICKI was (0.3±0.1) , significantly higher than [(0.2±0.2), P<0.05] in group B, and there were no significant differences (P>0.05) as respect to FPG, insulin and HOMA-B in the two groups; before treatment, there was no significant difference in blood lipid profile, such as blood low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and total cholesterol (TC) between the two groups (P>0.05), and at the end of 12 week observation, the blood LDL level in group A was (120.7±23.7) mg/dl, significantly lower than [(149.0±33.4) mg/dl, P<0.05] in group B, blood TC level was (197.6±40.7) mg/dl, significantly lower than [(230.5±42.8) mg/dl, P<0.05], and blood TG level was (176.2±75.0) mg/dl, significantly lower than [(186.4±63.7) mg/dl, P<0.05], while blood HDL level was (43.5±7.4) mg/dl, significantly higher than [(40.9±8.2) mg/dl, P< 0.05) in group B; there was no significant difference in serum malondialdehyde (MDA) between the two groups [(60.6±35.2) μ mol/l vs. (60.7±36.2) μmol/l, P > 0.05], while at the end of 12 week observation, serum MDA level in group A was [(55.5±35.8) μmol/l, significantly lower than [(60.3±34.3) μmol/l, P<0.05] in group B. Conclusion The application of calorie restriction diets might effectively improve insulin resistance, blood lipid profile and oxidative stress in patients with NAFLD, which is worth further study in multi-central clinical practice.

Key words: Nonalcoholic fatty liver disease, Calorie-restricted diets, Insulin resistance, Total cholesterol, Triglyceride, Oxidative stress