Abstract: Objective The aim of this study was to investigate the efficacy of cetylcysteine combined with magnesium isoglycyrrhizinate in treatment of patients with drug-induced liver injuries (DILI). Methods 100 patients with DILI were randomly divided into observation (n=50) and control group (n=50) in this study. The patients in the control group were treated with magnesium isoglycyrrhizinate, and those in the observation group received acetylcysteine and magnesium isoglycyrrhizinate combination for 4 weeks. Serum malonaldehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6) and procalcitonin (PCT) levels were assayed in all the patients. Results At the end on the observation, serum bilirubin, aspartate aminotransferase, alanine aminotransferase and glutamic transpeptidase levels in the combination group were(14.2±4.6)μmol/L,(62.9±6.8)U/L,(67.5±6.9) and (54.9±8.9)U/L, significantly lower than 【(21.4±7.3)μmol/L, (90.3±8.4)U/L, (86.4±7.5)U/L and (63.6±6.4), respectively, P<0.05】 in the control; serum MDA level was (4.8±0.7)μmol/L, much lower than 【(6.2±1.1)μmol/L, P<0.05】, serum SOD and GSH-Px levels were (81.5±7.9)U/L and (124.7±9.9)U/L, significantly higher than 【(75.5±8.3)U/L and (92.6±8.7)U/L, respectively, P<0.05】, serum IL-6 and PCT levels were (4.2±0.7)pg/L and (0.3±0.1)ng/L, significantly lower than 【(6.6±1.2)pg/L and (0.5±0.1)ng/L, respectively, P<0.05】 in the control. Conclusion The combination of magnesium isoglycyrrhizinate and acetylcysteine in treatment of patients with DILI is efficacious for short-term observation, which might be related to the inhibition of inflammatory reaction and oxidative stress.

Key words: Drug-induced liver injury, Acetylcysteine, Magnesium isoglycyrrhizinate, Oxidative stress, Inflammatory reaction, Therapy