Abstract: Objective The aim of this study was to explore the predictive value of serum glycosylated hemoglobin (HbA1c) and interleukin-6 (IL-6) levels on the risk of nonalcoholic fatty liver disease (NAFLD). Methods A total of 658 individuals were recruited in this study, and all of them underwent a comprehensive physical examination in our hospital between March 2014 and September 2015. Blood HbA1c and serum IL-6 levels were assayed, and Logistic analysis was applied to show the independent risk factors for NAFLD. Results Out the 658 individuals for physical check-up, 86 cases(13.1%) were found having NAFLD during the three-year follow-up by sonography; the BMI in patients with NAFLD was (26.4±2.5)kg/m², significantly higher than [(21.3±2.6) kg/m², P＜0.05] in 572 healthy persons; serum ALT, AST and GGT levels in patients with NAFLD were (55.1±7.2)U/L, (63.1±9.3)U/L and (73.6±6.2)U/L, significantly higher than [(23.5±6.3)U/L, (21.7±4.4)U/L and(25.1±6.4)U/L, respectively, P＜0.05] in the healthy persons; blood TG, LDL-C,FPG and2hPG levels in patients with NAFLD were (2.5±1.1)mmol/L,(1.1±0.2)mmol/L,(5.8±1.0)mmol/L and (7.6±2.3)mmol/L, significantly different as compared to [(1.2±0.3)mmol/L, (1.4±0.3)mmol/L,(5.0±0.8)mmol/L and (6.6±2.1)mmol/L, respectively, P＜0.05] in healthy persons; blood HbA1c in patients with NAFLD was (6.0±0.9)%, significantly higher than [(5.0±0.6)%, P＜0.05] and serum IL-6 level was (13.3±4.2)ng/L, significantly higher than [(3.1±0.8)ng/L, P＜0.05] in the healthy persons; Logistic analysis showed than elevated blood HbA1c(OR=1.355, 95%CI:1.121-2.315) and serum IL-6 levels(OR=1.368, 95%CI:1.056-2.685) were the risk factors for the occurrence of NAFLD. Conclusion Abnormal elevation of serum glycosylated hemoglobin and IL-6 levels might hint to a certain degree the happening of nonalcoholic fatty liver disease in the future, which must be concerned in clinical practice.

Key words: Nonalcoholic fatty liver disease, Glycated hemoglobin, Interleukin-6, Prediction