Abstract: Objective The aim of this study was to investigate the diagnostic efficacy of ¹⁸F-FDG PET/CT scan in patients with intrahepatic cholangiocarcinoma (ICC).Methods 107 patients with ICC and 107 healthy persons underwent ¹⁸F-FDG PET/CT scan between January 2017 and January 2020, and the TNM staging of tumor was evaluated and the standard uptake value maximum (SUVmax) was culculated. All patients received tumor resection.Results The SUVmax in patients with ICC stage Ⅰ was (4.1 ± 1.1), in patients with stage Ⅱ was (7.2 ± 1.5), and in patients with stage Ⅲ was (9.3 ± 1.8), all significantly higher than [(2.0 ± 0.9) , P<0.05] in healthy persons; the FDG PET/CT scan showed TNM stage Ⅰ in 35 cases, stage Ⅱ in 47 cases, and stage Ⅲ in 25 cases, and the post-operational histopathological examination demonstrated TNM stage Ⅰ, stage Ⅱ and stage Ⅲ were34 cases, 48 cases and 24 cases, respectively; the sensitivity (Se) of ¹⁸ F - FDG PET/CT scan in the diagnosis of patients with ICC TNM stage Ⅰ was 0.968, the specificity (Sp) was 0.500,the accuracy (Ac) was 0.914, the positive predictive value (PPV) was 0.938, and the negative predictive value (NPV) was 0.667, in the diagnosis of patients with ICC TNM staging Ⅱ, the Se was 0.976, the Sp was 0.667, the Ac was 0.956, the PPV was 0.976, and the NPV was 0.667, and in the diagnosis of patients with ICC TNM staging Ⅲ, the Se was 0.955, the Sp was 0.667, the Ac was 0.920, the PPV was 0.955, and the NPV was 0.667.Conclusion The application of ¹⁸F-FDG PET/CT scan is helpful for the diagnosis and assessment of TNM stage in patients ICC.

Key words: Intrahepatic cholangiocarcinoma, ¹⁸F-fluorodeoxyglucose, Positron emission computed tomography, TNM staging, Diagnosis